Neurotrophin-3 Prevents the Proximal Accumulation of Neurofilament Proteins in Sensory Neurons of Streptozocin-Induced Diabetic Rats

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Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic rats.

The relation between neurofilament expression and/or phosphorylation in the proximal versus distal components of the sensory peripheral neuraxis was studied and related to disorders in structure and function of the distal axon of streptozocin (STZ)-induced diabetic rats studied for 14 weeks. The ability of neurotrophin-3 (NT-3) to prevent abnormalities in neurofilament biology was also investig...

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Diabetes mellitus is a group of metabolic disorders characterized by elevated blood sugarand abnormalities in insulin secretion and action. There are many anti-diabetic plants, whichmight supply useful sources for developing new medicines that can be used in treatment ofdiabetes mellitus. The primary objective of the present investigation is to evaluate the antidiabeticproperties of the aerial ...

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ژورنال

عنوان ژورنال: Diabetes

سال: 2003

ISSN: 0012-1797,1939-327X

DOI: 10.2337/diabetes.52.9.2372